The AIDS Immunopathology Unit was set up in 2000 at Instituto de Salud Carlos III under the leadership of Pepe Alcamí. Our work aims at the comprehension of the pathogenesis of HIV-1, the causal agent of AIDS, and from this knowledge contribute to the development of vaccines and new drugs, including those designed to cure HIV.
Our group is focused on the interaction between viral envelope and receptors that allow its entry into the cell, the functions of cellular restriction factors that protect them against viral infection and the mechanisms by which HIV is able to remain latent in the infected cell. More recently, we have initiated a new work line about the genetic mechanisms that determine the progression or the control of HIV infection, and we have strengthened the line of study dedicated to neutralizing antibodies and vaccines. In addition, one of our lines of research is devoted to study the antiviral potential, including microbicide potential, of different drugs.